J. Golebiowski

Jérôme Golebiowski

      • Professor
      • Adjunct Professor at DGIST, Rep. of Korea
    • Member of the national CNRS committee, section 20
  •  

Molecular Modeling, psychophysiology: from receptor to behavior: My research projects are focused on ligand-receptor systems. They are centered on the  description of the molecular basis of chemical senses and more particularly the sense of smell. The long-term project is to redefine structure-odor relationships with the take into account of odorant receptors expressed in our neurons. In parallel, we are interested in the link between the structure of an odorant and the emotion.

  • Ongoing research projects:

     

    • InsectOR (2019-2020): Structure-function relationships of insect Odorant Receptors
    • OBP-Optinose (2019-2022): Odorant Binding Proteins-based biomimetic optical nose
    • ChemoSuz (2019-2021):  Chemogenetic characterization of the egg-laying behavior of the fruit pest species Drosophila suzukii
    • DoctOR (PRC Korea 2018-2019): Targeting Odorant receptors for healing your body and your mind
    • CrackOlf (2018-2019): Cracking Olfactory receptor activation by computational tools
    • PrediScent (2018-2019): Numerical models for predicting smell and emotion from chemical features
    • Demeter (2017-2021):  Less pesticides and more food!
    • The NeurOlf (2015-2019) Computational Research in Neuroscience: Predicting odorant-dependent and independent olfactory neuron activation based on receptor dynamics
  • The sweet smell of success of the group: 
    • Jody Pacalon and Cedric Bouysset are awarded a 1st year thesis bursary from GIRACT
    • Jody Pacalon is funded by the Roudnitska fondation for a PhD thesis (2018-2021)
    • cracking the olfactory code, CNRS news
    • “Dessine-moi une odeur !” by UCA News
    • Caroline Bushdid was awarded by the Laffitte prize in 2018
    • Xiajing Cong‘s post-doc is funded by DFG (2017-2019) to study GPCR activation

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  • Selected publications:

Mammalian class I odorant receptors exhibit a conserved vestibular binding pocket

 Agonists of G Protein-Coupled Odorant Receptors are Predicted from Chemical Features

ACIE Odorant Receptor 7D4 activation dynamics

 Responsiveness of G protein-coupled odorant receptors is partially attributed to the activation mechanism

 Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors

  Structure–odour relationships reviewed in the postgenomic era

  G protein-coupled odorant receptors: From sequence to structure

 Discrimination between Olfactory Receptors agonists and non-agonists

  • Recent publications: 2012-

Y. Wang, A. Zajac, W. Lei, C. Christensen, R. Margolskee, J. Golebiowski, H. Zhao*, S. Fiorucci*, P. Jiang*
Metal ions activate the human taste receptor TAS2R7
Submitted 2019

Licon CC, Bosc G, Sabri M, Mantel M, Fournel A, Bushdid C, Golebiowski J, Robardet C, Plantevit M, Kaytoue M, Bensafi M*
Chemical features mining provides new descriptive structure-odor relationships
Plos Computational Biology, 2019, in revision

 X. Cong*, JB. Chéron, J. Golebiowski, S. Antonczak, S. Fiorucci*
Allosteric modulation mechanism of the mGluR5 transmembrane domain
Journal of Chemical Information and Modeling, 2019, in revision

 X. Cong, Q. Zheng, W. Ren, JB. Chéron, S. Fiorucci, T. Wen, C. Zhang, H. Yu*, J. Golebiowski*, Y. Yu*
Zebrafish olfactory receptors ORAs differentially detect bile acids and bile salts
The Journal of Biological Chemistry, 2019, in press

 J.B. Chéron, A. Soohoo, J. Golebiowski, S. Antonczak, P. Jiang*, S. Fiorucci*
Conserved residues control the allosteric signalling pathway of the mammalian sweet taste receptor
Chemical Senses, 2019, in press

 C. Bushdid#, C.A. de March#, J. Topin, M. Do, H. Matsunami*, J. Golebiowski*
Mammalian class I odorant receptors exhibit a conserved vestibular binding pocket
Cellular and Molecular Life Sciences, 2019, 76, 995-1004

 X. Cong*, J. Golebiowski*
Allosteric Na+-binding site modulates CXCR4 activation
Physical Chemistry Chemical Physics, 2018, 20, 24915-24920

 X. Cong*, S. Fiorucci, J. Golebiowski*
Activation dynamics of the Neurotensin Receptor 1
The Journal of Chemical Theory and Computation, 2018, 14(8), 4467-4473

 C. Bushdid, C.A. de March, S. Fiorucci, H. Matsunami*, J. Golebiowski*
Agonists of G protein-coupled odorant receptors are predicted from chemical features
The Journal of Physical Chemistry Letters, 2018, 9, 2235-2240

 C.A. de March, J. Topin, E. Bruguera, G. Novikov, K. Ikegami, H. Matsunami*, J. Golebiowski*
Odorant receptor 7D4 activation dynamics
Angewandte Chemie Int. Ed., 2018, 57, 4554-4558

 C. Bushdid, C.A. de March, H. Matsunami*, J. Golebiowski*
Numerical Models and In Vitro Assays to Study Odorant Receptors.
Methods in Molecular Biology, 2018, 1820:77-93

 X. Cong*, J. Topin, J. Golebiowski*
Class A GPCRs: structure, function, modeling and structure-based ligand design
Current Pharmacological Design, 2017, 16;23(29), 4390-4409

S-J Yoo, S-E. Ryu, S. Kim, J. Golebiowski, H.S. Han, C. Moon
Smell. In Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, 2017. ISBN 9780128093245

 J.B. Chéron, J. Golebiowski, S. Antonczak, L. Briand, S. Fiorucci
Ces molécules qui éveillent nos papilles
L’Actualité Chimique, Mars 2017

 T. Tong, S-E. Ryu, Y. Mi, C.A. de March, C. Bushdid, J. Golebiowski, C. Moon, T. Park
Identification of olfactory receptor 10J5 as a therapeutic target for hepatic steatosis via cAMP-PKA pathway
Scientific Reports, 7(1) · August 2017

 J.B. Chéron, J. Golebiowski, S. Antonczak, S. Fiorucci
The anatomy of mammalian sweet taste receptors
Proteins, Structure, Function and Bioinforamtics, 2017, 85, 332–341

 J. Diharce, J. Golebiowski, S. Antonczak
Simulations (moléculaires) et vérités.
L’Actualité Chimique, Février 2017

 A. Gros, V. Manera, C A. de March, N. Guevara, A. Koenig, P. Robert, J. Golebiowski, R. David
Olfactory disturbances in aging with and without dementia: towards new diagnostic tools.
Journal of Laryngology and Otology, 2017 ;131(7):572-579

 J.B. Chéron, I. Casiuc, J. Golebiowski, S. Antonczak, S. Fiorucci
Sweetness prediction of natural compounds
Food Chemistry 2017, 221, 1421-1425

 G. Bosc, J. Golebiowski, M. Bensafi, C. Robardet, M. Plantevit, J.F. Boulicaut, M. Kaytoue
Local Subgroup Discovery for Eliciting and Understanding New Structure-Odor Relationships
Discovery Science, 2016, 9956, 19-34

 C. Bushdid, C.A. de March, J. Topin, S. Antonczak, M. Bensafi, J. Golebiowski*
Ces molécules qui nous mènent par le bout du nez. Le code moléculaire de la perception des odeurs
L’Actualité Chimique, Avril 2016.

 J. Diharce, J. Golebiowski,S. Fiorucci*, S. Antonczak*
Fine-tuning of microsolvation and hydrogen bond interaction regulates substrate channelling in the course of flavonoid biosynthesis
Physical Chemistry Chemical Physics, 2016, 18, 10337-10345

 Y. Yu, C.A. de March, M. Ni, K. Adipietro, J. Golebiowski*, H. Matsunami*, M. Ma*
Responsiveness of G protein-coupled odorant receptors is partially attributed to the activation mechanism
Proceedings of the National Academy of Science of the United States of America, 2015, 112 (48), 14966-14971

 C.A de March, SK Kim, W.A. Goddard III, J. Golebiowski*
G Protein-Coupled Odorant Receptors: from sequence to structure
Protein Science, 2015, 24 (9), 1543-1548

 C.A. de March, Y. Yu, M. Ni, K. Adipietro, H. Matsunami*, M. Ma*, J. Golebiowski*
Conserved residues control activation of mammalian G Protein-Coupled Odorant Receptors
Journal of the American Chemical Society, 2015, 137 (26), 8611-8616

 C.A de March, S. Ryu, G. Sicard, C. Moon, J. Golebiowski*
Structure-odor relationships reviewed in the postgenomic era
Flavour & Fragrance Journal, 2015, 30 (5), 342-361