golebiowski

Jérôme Golebiowski

  • Professor
  • Adjunct Professor at DGIST, Rep. of Korea
  • Head of the CDIEC
  • Co-PI of the Odorant-Odeur-Olfaction CNRS Group of Research
  • Member of the national CNRS committee, section 20

Molecular Modeling, psychophysiology: from receptor to behavior: My research projects are focused on ligand-receptor systems. They are centered on the  description of the molecular basis of chemical senses and more particularly the sense of smell. The long-term project is to redefine structure-odor relationships with the take into account of odorant receptors expressed in our neurons. In parallel, we are interested in the link between the structure of an odorant and the emotion.

  • Ongoing research projects:
    • The DoctOR project is funded by CNRS (PRC Korea 2018-2019): Targeting Odorant receptors for healing your body and your mind
    • The CrackOlf Project is funded by Univ. Côte d’Azur (2018-2019): Cracking Olfactory receptor activation by computational tools
    • The PrediScent Project is funded by Univ. Côte d’Azur (2018-2019): Numerical models for predicting smell and emotion from chemical features
    • The Demeter project is funded by ANR (2017-2021):  Less pesticides and more food!
    • The Emoton project is funded by the Interdisciplinary Section of CNRS (2016-2018) : Olfaction as a tool to promote motivation and autonomy 
    • The NeurOlf project is funded by the call jointly launched by ANR and NSF (2015-2018) in Computational Research in Neuroscience: Predicting odorant-dependent and independent olfactory neuron activation based on receptor dynamics
  • The sweet smell of success of my group: 
    • “Dessine-moi une odeur !” by UCA News
    • Caroline Bushdid was awarded by the Laffitte prize in 2018
    • Xiajing Cong‘s post-doc is funded by DFG (2017-2019) to study GPCR activation
    • Caroline Bushdid is funded by the GEN foundation in 2016-2017
    • Caroline Bushdid is awarded by GIRACT as first year PhD student in 2016
    • Jéremie Topin‘s post-doc fellowship is funded for 2 years (2016-2018) by the city of NICE for developping a project on rational odorant stimulation to trigger emotional effects, notably for Alzheimer disease patients.
    • Caroline Bushdid is funded by the Roudnitska fondation for a PhD thesis (2015-2018): Structure-odor relationhips. From receptors to behavior.

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  • Selected publications:

 Agonists of G Protein-Coupled Odorant Receptors are Predicted from Chemical Features

ACIE Odorant Receptor 7D4 activation dynamics

   Responsiveness of G protein-coupled odorant receptors is partially attributed to the activation mechanism

  Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors

  Structure–odour relationships reviewed in the postgenomic era

  G protein-coupled odorant receptors: From sequence to structure

 Discrimination between Olfactory Receptors agonists and non-agonists

  • Recent publications: 2012-
C. Bushdid, C.A. de March, S. Fiorucci, H. Matsunami*, J. Golebiowski*
Agonists of G Protein-Coupled Odorant Receptors are Predicted from Chemical Features
The Journal of Physical Chemistry Letters, 2018, in press

C.A. de March, J. Topin, E. Bruguera, G. Novikov, K. Ikegami, H. Matsunami*, J. Golebiowski*
Odorant receptor 7D4 activation dynamics
Angewandte Chemie International Edition, 2018, 57, 4554-4558

C. Bushdid, C.A. de March, H. Matsunami, J. Golebiowski*
Molecular modeling of Odorant Receptors.
Methods in Molecular Biology, 2018, in press

X. Cong*, J. Topin, J. Golebiowski*
Class A GPCRs: structure, function, modeling and structure-based ligand design
Current Pharmacological Design, 2017, 16;23(29), 4390-4409

S-J Yoo, S-E. Ryu, S. Kim, J. Golebiowski, H.S. Han, C. Moon
Smell. In Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, 2017. ISBN 9780128093245

J.B. Chéron, J. Golebiowski, S. Antonczak, L. Briand, S. Fiorucci
Ces molécules qui éveillent nos papilles
L'Actualité Chimique, Mars 2017

T. Tong, S-E. Ryu, Y. Mi, C.A. de March, C. Bushdid, J. Golebiowski, C. Moon, T. Park
Identification of olfactory receptor 10J5 as a therapeutic target for hepatic steatosis via cAMP-PKA pathway
Scientific Reports, 7(1) · August 2017

J.B. Chéron, J. Golebiowski, S. Antonczak, S. Fiorucci
The anatomy of mammalian sweet taste receptors
Proteins, Structure, Function and Bioinforamtics, 2017, 85, 332–341

J. Diharce, J. Golebiowski, S. Antonczak
Simulations (moléculaires) et vérités.
L'Actualité Chimique, Février 2017

A. Gros, V. Manera, C A. de March, N. Guevara, A. Koenig, P. Robert, J. Golebiowski, R. David
Olfactory disturbances in aging with and without dementia: towards new diagnostic tools.
Journal of Laryngology and Otology,  2017 ;131(7):572-579

J.B. Chéron,I. Casiuc, J. Golebiowski, S. Antonczak, S. Fiorucci
Sweetness prediction of natural compounds
Food Chemistry 2017, 221, 1421-1425

G. Bosc, J. Golebiowski, M. Bensafi, C. Robardet, M. Plantevit, J.F. Boulicaut, M. Kaytoue
Local Subgroup Discovery for Eliciting and Understanding New Structure-Odor Relationships
Discovery Science, 2016, 9956 (series Lecture Notes in Computer Science), 19-34

C. Bushdid, C.A. de March, J. Topin, S. Antonczak, M. Bensafi, J. Golebiowski*
Ces molécules qui nous mènent par le bout du nez. Le code moléculaire de la perception des odeurs
L’Actualité Chimique, Avril 2016.

J. Diharce, J. Golebiowski,S. Fiorucci*, S. Antonczak*
Fine-tuning of microsolvation and hydrogen bond interaction regulates substrate channelling in the course of flavonoid biosynthesis
Physical Chemistry Chemical Physics, 2016, 18, 10337-10345

Y. Yu, C.A. de March, M. Ni, K. Adipietro, J. Golebiowski*, H. Matsunami*, M. Ma*
Responsiveness of G protein-coupled odorant receptors is partially attributed to the activation mechanism
Proceedings of the National Academy of Science of the United States of America, 2015, 112 (48), 14966-14971

C.A de March, SK Kim, W.A. Goddard III, J. Golebiowski*
G Protein-Coupled Odorant Receptors: from sequence to structure
Protein Science, 2015, 24 (9), 1543-1548

C.A. de March, Y. Yu, M. Ni, K. Adipietro, H. Matsunami*, M. Ma*, J. Golebiowski*
Conserved residues control activation of mammalian G Protein-Coupled Odorant Receptors
Journal of the American Chemical Society, 2015, 137 (26), 8611-8616

C.A de March, S. Ryu, G. Sicard, C. Moon, J. Golebiowski*
Structure-odor relationships reviewed in the postgenomic era
Flavour & Fragrance Journal, 2015, 30 (5), 342-361

Kufareva, Irina et al.
Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
Structure, 2014, 22 (8), 1120 - 1139

C.A. de March & J. Golebiowski*
A computational microscope focused on the sense of smell
Biochimie, 2014, 107, 3-10

J. Topin, C.A. de March, L. Charlier, C. Ronin, S. Antonczak, J. Golebiowski*
Discrimination between Olfactory Receptors agonists and non-agonists
Chemistry, A European Journal, 2014, 20, 10227-10230

C. Delasalle, C.A.de March, U. Meierhenrich, H. Brevard, J. Golebiowski*, N. Baldovini*
Structure-odor Relationships of β-Santalol analogues
Chemistry & Biodiversity, 2014, 11, 1843-1860

N. Le Breton, M. Martinho,  K. Kabytaev, J. Topin,  E. Miléo, D. Blocquel, J. Habchi, S. Longhi, A. Rockenbauer, J. Golebiowski, B. Guigliarelli, S. R. A. Marque, V. Belle*
Diversification of EPR signatures in Site directed spin labeling using a β-phosphorylated nitroxide,
PhysChemChemPhys, 2014, 16, 4202-4209

J. Topin, J. Diharce, S. Fiorucci, S.Antonczak*, J. Golebiowski*
O2 migration rates in [NiFe] hydrogenases. A joint approach combining free energy calculations and kinetic modelling,
Journal of Physical Chemistry B, 2014, 118, 676-681

J. Golebiowski*, L. Charlier, J. Topin, S. Fiorucci, S. Antonczak
Molecular features underlying the chemoreception of Odorant Binding Proteins and Olfactory Receptors. Insights from molecular modeling and biophysical data.
Chapter 96, in Flavour Sciences, 2013, 519-524

L. Charlier, J. Topin, C.A. de March, P. Lai, C. Crasto, J. Golebiowski*
Molecular Modelling of Olfactory Receptors. 
Methods in Molecular Biology2013, 1003, 53-65

J-M. Heydel, A-M. Le Bon, P. Faure, F. Neiers, Y. Artur, J. Golebiowski, L. Briand
Odorant-binding proteins and xenobiotic metabolizing enzymes: implications in olfactory peri-receptor events.
The Anatomical Record, 2013, 293, 1333-1345.

L. Charlier, J. Topin,  C. Ronin, SK. Kim, W.A. Goddard III, R. Efremov,  J. Golebiowski*
How broadly tuned olfactory receptors equally recognize their agonists. Human OR1G1 as a test case.
Cellular and Molecular Life Sciences, 2012, 69, 4205-4213

J. Golebiowski,* J. Topin, L. Charlier, L. Briand
Interaction between odorants and proteins involved in the perception of smell. The case of Odorant-Binding Proteins probed by molecular modeling and biophysical data.
Flavour and Fragrance Journal, 2012, 27, 445-453.

J. Golebiowski, X. Fernandez
Chapitre 1.1. Chimie des substances odorantes et physiologie de l’olfaction.
in «Les Huiles Essentielles. Tradition et Innovation». Editions Vuibert, 2012 

J. Topin, M. Rousset, S. Antonczak, J. Golebiowski*
Kinetics and thermodynamics of gas diffusion in a NiFe hydrogenase
Proteins, structure Function and Bioinformatics 2012, 80, 677-682

M.Maïbèche, JM. Heydel, AM. Le Bon, J. Golebiowski, L. Briand
Chap. 3.2. Périrécéption et protéines porteuses (Perireception and Odorant Binding Proteins)
in “ODORAT et GOUT : de la neurobiologie des sens chimiques aux applications agronomiques, industrielles et médicales” (380 pages), Editions QUAE, 2012.